<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rudriger Bock</style></author><author><style face="normal" font="default" size="100%">Jörg Meier</style></author><author><style face="normal" font="default" size="100%">László Gábor Nyúl</style></author><author><style face="normal" font="default" size="100%">Simone Wärntges</style></author><author><style face="normal" font="default" size="100%">Georg Michelson</style></author><author><style face="normal" font="default" size="100%">Joachim Hornegger</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Joachim Hornegger</style></author><author><style face="normal" font="default" size="100%">Ernst W Mayr</style></author><author><style face="normal" font="default" size="100%">Sergey Schookin</style></author><author><style face="normal" font="default" size="100%">Hubertus Feußner</style></author><author><style face="normal" font="default" size="100%">Nassir Navab</style></author><author><style face="normal" font="default" size="100%">Yuri V. Gulyaev</style></author><author><style face="normal" font="default" size="100%">Kurt Höller</style></author><author><style face="normal" font="default" size="100%">Victor Ganzha</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Appearance-based Approach to Extract an Age-related Biomarker from Retinal Images</style></title><secondary-title><style face="normal" font="default" size="100%">3rd Russian-Bavarian Conference on Bio-Medical Engineering, Proceedings</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2007</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">Friedrich-Alexander University Erlangen-Nuremberg</style></publisher><pub-location><style face="normal" font="default" size="100%">Erlangen</style></pub-location><volume><style face="normal" font="default" size="100%">1</style></volume><pages><style face="normal" font="default" size="100%">127 - 131</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We present an appearance-based method that extracts a new age-related biomarker from retina images. The Principal Component Analysis is applied on intensity values of the illumination corrected green channel of fundus images. The algorithm does not use segmentation, is robust and shows a high range of reliability. It identiﬁed an age-related feature with a strong inﬂuence of the temporal parapapillary area and the optic nerve head. The feature correlates with chronological age of the participants and is signiﬁcantly inﬂuenced by the appearance of cardiovascular risk factors such as smoking and hypertension, and thus it can be designated a biomarker. We extract and validate a medical parameter from retina images applying a purely data-driven approach without using any prior knowledge.&lt;/p&gt;</style></abstract><work-type><style face="normal" font="default" size="100%">Conference paper</style></work-type></record></records></xml>