<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ágnes Janovszky</style></author><author><style face="normal" font="default" size="100%">Andrea Szabó</style></author><author><style face="normal" font="default" size="100%">Renáta Varga</style></author><author><style face="normal" font="default" size="100%">Dénes Garab</style></author><author><style face="normal" font="default" size="100%">Mihály Boros</style></author><author><style face="normal" font="default" size="100%">Csilla Mester</style></author><author><style face="normal" font="default" size="100%">Nikolett Beretka</style></author><author><style face="normal" font="default" size="100%">Tamás Zombori</style></author><author><style face="normal" font="default" size="100%">Hans-Peter Wiesmann</style></author><author><style face="normal" font="default" size="100%">Ricardo Bernhardt</style></author><author><style face="normal" font="default" size="100%">Imre Ocsovszki</style></author><author><style face="normal" font="default" size="100%">Péter Balázs</style></author><author><style face="normal" font="default" size="100%">József Piffkó</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Periosteal microcirculatory reactions in a zoledronate-induced osteonecrosis model of the jaw in rats</style></title><secondary-title><style face="normal" font="default" size="100%">Clinical Oral Investigations</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2015</style></date></pub-dates></dates><publisher><style face="normal" font="default" size="100%">Springer</style></publisher><volume><style face="normal" font="default" size="100%">19</style></volume><pages><style face="normal" font="default" size="100%">1279-1288</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;div class=&quot;AbstractSection&quot; id=&quot;ASec1&quot;&gt;&lt;h3 class=&quot;Heading&quot;&gt;Objectives&lt;/h3&gt;&lt;p class=&quot;Para&quot; id=&quot;Par1&quot;&gt;Nitrogen-containing bisphosphonates induce osteonecrosis mostly in the jaw and less frequently in other bones. Because of the crucial role of periosteal perfusion in bone repair, we investigated zoledronate-induced microcirculatory reactions in the mandibular periosteum in comparison with those in the tibia in a clinically relevant model of bisphosphonate-induced medication-related osteonecrosis of the jaw (MRONJ).&lt;/p&gt;&lt;/div&gt;&lt;div class=&quot;AbstractSection&quot; id=&quot;ASec2&quot;&gt;&lt;h3 class=&quot;Heading&quot;&gt;Materials and methods&lt;/h3&gt;&lt;p class=&quot;Para&quot; id=&quot;Par2&quot;&gt;Sprague–Dawley rats were treated with zoledronate (ZOL; 80 i.v. μg/kg/week over 8&amp;nbsp;weeks) or saline vehicle. The first two right mandibular molar teeth were extracted after 3&amp;nbsp;weeks. Various systemic and local (periosteal) microcirculatory inflammatory parameters were examined by intravital videomicroscopy after 9&amp;nbsp;weeks.&lt;/p&gt;&lt;/div&gt;&lt;div class=&quot;AbstractSection&quot; id=&quot;ASec3&quot;&gt;&lt;h3 class=&quot;Heading&quot;&gt;Results&lt;/h3&gt;&lt;p class=&quot;Para&quot; id=&quot;Par3&quot;&gt;Gingival healing disorders (∼100&amp;nbsp;%) and MRONJ developed in 70&amp;nbsp;% of ZOL-treated cases but not after saline (shown by micro-CT). ZOL induced significantly higher degrees of periosteal leukocyte rolling and adhesion in the mandibular postcapillary venules (at both extraction and intact sites) than at the tibia. Leukocyte NADPH-oxidase activity was reduced; leukocyte CD11b and plasma TNF-alpha levels were unchanged.&lt;/p&gt;&lt;/div&gt;&lt;div class=&quot;AbstractSection&quot; id=&quot;ASec4&quot;&gt;&lt;h3 class=&quot;Heading&quot;&gt;Conclusion&lt;/h3&gt;&lt;p class=&quot;Para&quot; id=&quot;Par4&quot;&gt;Chronic ZOL treatment causes a distinct microcirculatory inflammatory reaction in the mandibular periosteum but not in the tibia. The local reaction in the absence of augmented systemic leukocyte inflammatory activity suggests that topically different, endothelium-specific changes may play a critical role in the pathogenesis of MRONJ.&lt;/p&gt;&lt;/div&gt;&lt;div class=&quot;AbstractSection&quot; id=&quot;ASec5&quot;&gt;&lt;h3 class=&quot;Heading&quot;&gt;Clinical relevance&lt;/h3&gt;&lt;p class=&quot;Para&quot; id=&quot;Par5&quot;&gt;This model permits for the first time to explore the microvascular processes in the mandibular periosteum after chronic ZOL treatment. This approach may contribute to a better understanding of the pathomechanism and the development of strategies to counteract bisphosphonate-induced side effects.&lt;/p&gt;&lt;/div&gt;&lt;p&gt;&amp;nbsp;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Journal article</style></work-type><section><style face="normal" font="default" size="100%">1279</style></section></record></records></xml>